Development of Sedative Dexmedetomidine Sublingual In Situ Gels: In Vitro and In Vivo Evaluations

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages: 220
Authors:
Journal: Pharmaceutics MDPI Volume: 14
Keywords : Development , Sedative Dexmedetomidine Sublingual , Situ Gels:    
Abstract:
Intravenous dexmedetomidine (DEX) is currently approved by the FDA for the sedation of intubated patients in intensive care units to reduce anxiety and to augment postoperative analgesia. Bradycardia and hypotension are limitations associat
   
     
 
       

Author Related Publications

  • Nora Gamal Mohamed Abdallah Essa, "Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides", Elsevier Inc, 2014 More
  • Nora Gamal Mohamed Abdallah Essa, "Buccoadhesive tablets for delivery of verapamil Hcl: Design, in-vitro analysis and in-vivo evaluation", Bull. Pharm. Sci., Assiut University, 2012 More
  • Nora Gamal Mohamed Abdallah Essa, "New approach for administration of doxazosin mesylate: comparative study between liquid and solid self-nanoemulsifying drug delivery systems", JK Welfare & Pharmascope Foundation, 2021 More
  • Nora Gamal Mohamed Abdallah Essa, "Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study", Wiley, 2019 More
  • Nora Gamal Mohamed Abdallah Essa, "Engineering of smart nanoconstructs for delivery of glucagon-like peptide-1 analogs", Elsevier B.V., 2021 More

Department Related Publications

  • Ahmed Samer Zedan, "Physicochemical characterization and dissolution properties of rofecoxib complexes with cyclodextrins", لايوجد, 1900 More
  • Ahmed Samer Zedan, "Preparation and characterization of rofecoxib solid dispersions with polyethylene glycols and urea", لايوجد, 1900 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes", لايوجد, 1900 More
  • Amr Selim Ahmed Ali Abu Lila, "Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration", Elsevier, 2013 More
  • Amr Selim Ahmed Ali Abu Lila, "Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin", Elsevier, 2012 More
Tweet