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Promising Role of Growth Hormone-Boosting Peptide in Regulating the Expression of Muscle-Specific Genes and Related MicroRNAs in Broiler Chickens
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Doaa Ibrahim Mohamed Aboelnazr
Staff Zu Site
Abstract In Staff Site
Journal:
animals MDPI
Volume:
Keywords :
Promising Role , Growth Hormone-Boosting Peptide in Regulating
Abstract:
In chickens, breast muscle is a key contributor to meat yield. Skeletal muscle development is a complex process regulated by many genes, transcription factors, and miRNA through different muscle signaling pathways. The latter are activated by synthetic growth hormoneboosting peptides (GHBP) that mimic the effects of endogenous growth factors, mainly insulinlike growth factor-1 (IGF-1)/mammalian target of rapamycin (mTOR), and modulate myostatin gene expression. The molecular mechanisms underlying chicken breast muscle development in relation to GHBP are still unclear. In the current study, the role of GHBP in a chicken’s growth rate, skeletal muscle development-related genes and myomiRs, serum bio-chemical parameters, and myofiber characteristics post-hatching was evaluated. Using of GHBP at a level of 200 g/kg positively regulated gene expression related to muscle growth and muscle-specific myomiRs. This was evidenced by upregulation of IGF-1, mTOR, myoD and myogenin genes, and miR-27b and miR-499 and downregulation of myostatin, Pax-3 and -7 genes and miR-1a, miR-133a, miR-133b, and miR-206 compared to the control group. Therefore, administration of GHBP at the level of 200 g/kg to broiler chicks can accelerate their growth by enhancing skeletal muscle development via controlling the transcription of breast muscle-related genes and associated myomiRs
Author Related Publications
Doaa Ibrahim Mohamed Aboelnazr, "Efficacy of Feeding Ensiled Corn Crop Residues to Sheep.", كلية الطب البيطري, 2009
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Doaa Ibrahim Mohamed Aboelnazr, "Nutritional Aspect of Recycling Plants By-Products and Crop Residues (Corn Stalk) in Sheep.", كلية الطب البيطري, 2009
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Doaa Ibrahim Mohamed Aboelnazr, "Impact of Fermented or Enzymatically Fermented Dried Olive Pomace on Growth, Expression of Digestive Enzyme and Glucose Transporter Genes, Oxidative Stability of Frozen Meat, and Economic Efficiency of Broiler Chickens", Frontiers, 2021
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Doaa Ibrahim Mohamed Aboelnazr, "Thymol nanoemulsion promoted broiler chicken’s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium", springer nature, 2021
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Doaa Ibrahim Mohamed Aboelnazr, "Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model", MDPI, 2021
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Department Related Publications
Mohammed Hessien Soliman Ahmed , "Evaluation of proteins in some soybean products. 3rd Scientific Conference for ", لايوجد, 1900
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Walaa Mahmoud Mohamed Abdelrazik , "تاثير الافلاتوكسين وعلاقتة بمستوى البروتين على صحة ومعدل النمو فى اصبعيات البلطى النيلى", لايوجد, 1900
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Walaa Mahmoud Mohamed Abdelrazik , "تاثير تحديد النظام الغذائى المبكر على معدلات النمو ومكونات الجسم ونمو ملحقات الجهاز الهضمى", لايوجد, 1900
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Rania Alsayed Mahmoud Elsayed, "THE EFFECT OF ALOE VERA GEL AND DREIED CAMPHOR LEAVES ON GROWTH PERFORMANCE, BODY COMPOSITION, IMMUNITY, SOME BLOOD PARAMETERS AND ECONOMIC EFFECNCY IN NILE TILAPIA (OREOCHROMIS NILOTICUS) أثر إضافة الصبار وأوراق الكافور المجففة على معدل", The 6th Global fisheries and Aquaculture research conference, 2013
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Rania Alsayed Mahmoud Elsayed, "Supplementation of Herbal Essential Oil Mixture to diet of Nile Tilapia and Evaluating Growth Performance, Health Status and Intestinal Histology تاثير إضافة زيوت خليط من الاعشاب الى عليقة اسماك البلطى النيلى على اداء النمو و الحالة الص", Zagazig University, 2014
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