Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies

Faculty Science Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Plos One Plos Volume:
Keywords : Quercetin/Zinc complex , stem cells: , , drug therapy , ameliorate    
Abstract:
Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior of quercetin (Q), which is a flavonoid, and its Zn (II) (Q/Zn) complex were studied and characterized based on elemental analysis, molar conductance, Fourier-transform infrared (FTIR) spectra, electronic spectra, proton nuclear magnetic resonance (H-1-NMR), thermogravimetric analysis, and transmission electron microscopy (TEM). FTIR spectral data revealed that Q acts as a bidentate ligand (chelating ligand) through carbonyl C(4) = O oxygen and phenolic C(3)-OH oxygen in conjugation with Zn. Electronic, FTIR, and H-1-NMR spectral data revealed that the Q/Zn complex has a distorted octahedral geometry, with the following chemical formula: [Zn(Q)(NO3)(H2O)(2)](center dot)5H(2)O. Diabetes was induced by streptozotocin (STZ) injection. A total of 70 male albino rats were divided into seven groups: control, diabetic untreated group and diabetic groups treated with either MSCs and/or Q and/or Q/Zn or their combination. Serum insulin, glucose, C-peptide, glycosylated hemoglobin, lipid profile, and enzymatic and non-enzymatic antioxidant levels were determined. Pancreatic and lung histology and TEM for pancreatic tissues in addition to gene expression of both SOD and CAT in pulmonary tissues were evaluated. MSCs in combination with Q/Zn therapy exhibited potent protective effects against STZ induced hyperglycemia and suppressed oxidative stress, genotoxicity, glycometabolic disturbances, and structural alterations. Engrafted MSCs were found inside pancreatic tissue at the end of the experiment. In conclusion, Q/Zn with MSC therapy produced a synergistic effect against oxidative stress and genotoxicity and can be considered potential ameliorative therapy against diabetes with pulmonary dysfunction, which may benefit against COVID-19.
   
     
 
       

Author Related Publications

  • Reham Zakaria Mustafa Mohammed Hamza, "Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats", SAGE, 2020 More
  • Reham Zakaria Mustafa Mohammed Hamza, "Synthesis ofN,N '-bis(1,5-dimethyl-2-phenyl-1,2-dihydro3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: "Suggested potent anti-inflammatory agent against COVID-19"", SAGE, 2020 More
  • Reham Zakaria Mustafa Mohammed Hamza, "Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats", SPRINGER, 2021 More
  • Reham Zakaria Mustafa Mohammed Hamza, "Improving the efficacy of garlic extract in African catfish against copper sulfate-induced immunological and histological effects", ElSevier, 2021 More
  • Reham Zakaria Mustafa Mohammed Hamza, "Silymarin and Nigella sativa extract ameliorate paracetamol induced oxidative stress and renal dysfunction in male mice", ElSevier, 2015 More

Department Related Publications

  • Soliman Syed Ahmed Ibrahim, "Protective potential of chamomile flowers and fennel seeds extracts against hemo- and immuno-toxicity of azathioprine in male Sprague-Dawley rats", Journal of Environmental Immunology and Toxicology, 2015 More
  • Mohamed Ali Mohammed Salamah, "Interleukin-1 Receptor Antagonist Gene Polymorphism And Resveratrol In Type 2 Diabetic Rats", Wulfenia Journal May (2016) Vol 23, No. 5: 179-189, 2016 More
  • Mohamed Ali Mohammed Salamah, "Histopathological Changes In Some Organs Exposed To Malathion And Dimethoate Insecticides And Its Cytogenetic Effects On Guinea Pigs, Cavia Porcellus.", The Egyptian Journal of Medical Sciences 33 (1): 697-709., 2012 More
  • Shereen Ahmadi Shafiq, "Gross anatomy and scanning electron microscopic study of the tongue of Egyptian Dabb lizard (Uromastyx aegyptia) in relation to feeding habits", IJARQG(USA), 2017 More
  • AbdulAziz AbdelFattah AbdulAziz, "Ameliorative and Anti-Inflammatory Properties of Thuja occidentalis in Phenytoin-Induced Hepatic and Renal Dysfunctions in Male Albino Rats.", Thai Society of Higher Education Institutes on Environment, 2022 More
Tweet