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Metabolic profiling and biological activities of the aerial parts of Micromeria imbricata Forssk. growing in Saudi Arabia
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Sahar Abdelaziz Mohamed Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Saudi Journal of Biological Sciences Production and hosting by Elsevier
Volume:
Keywords :
Metabolic profiling , biological activities , , aerial parts
Abstract:
The hydroalcoholic extract (MIT) of Micromeria imbricata (Forssk.) growing in Saudi Arabia in addition to the chloroform (MIC) and n-butanol (MIB) fractions were investigated for the first time using UPLC-ESIMS/MS. The analysis revealed the tentative identification of fifty-eight compounds including three organic acids, twenty-five phenolic compounds, three coumarins, two anthocyanins, twenty-one flavonoids, three terpenes, and one miscellaneous. Moreover, the therapeutic potential of M. imbricata (MIT) and its fractions (MIC and MIB) were determined by in vitro evaluation of their cytotoxic, antioxidant, and anti-obesity characteristics. The MIT extract showed the highest phenolic (125.23 ± 0.87 mg gallic acid equivalent/100 gm extract) and flavonoid (112.24 ± 2.45 mg quercetin equivalent/100 gm extract) contents followed by n-butanol and chloroform fractions. The MIT extract revealed a potent cytotoxic activity against HepG-2 (Hepatocellular carcinoma) and MCF-7 (Breast carcinoma) with IC 28.5 ± 2.0 and 35.2 ± 1.2 mg/mL, respectively. Additionally, the tested hydroalcoholic extract exhibited a significant DPPH scavenging activity with SC 50 28.4 ± 1.2 mg/mL and a remarkable lipase inhibitory activity with IC 54.2 ± 1.2 mg/mL. In conclusion, the current study presents the first insights into the phytochemical constituents and pharmacological properties of M. imbricata extract and its chloroform and n-butanol fractions. The results revealed that M. imbricata hydroalcoholic extract might be a prolific source of bioactive constituents with potent antioxidant, cytotoxic and anti-obesity potential. It might be a natural alternative therapy and nutritional strategy for obesity treatment.
Author Related Publications
Sahar Abdelaziz Mohamed Abdalaziz, "MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT", European Journal of Pharmaceutical and Medical Research, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Anticancer activity and concurrent analysis of ursolic acid, b-sitosterol and lupeol in three different Hibiscus species (aerial parts) by validated HPTLC method", Elsevier, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Chemical Composition and Biological Activities of the Aqueous Fraction of Parkinsonea aculeata L. Growing in Saudi Arabia", Elsevier, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Expression of Biphenyl Synthase Genes and Formation of Phytoalexin Compounds in Three Fire Blight-Infected Pyrus communis Cultivars", PLOS ONE, 2016
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Sahar Abdelaziz Mohamed Abdalaziz, "Concurrent analysis of bioactive triterpenes oleanolic acid and b-amyrin in antioxidant active fractions of Hibiscus calyphyllus, Hibiscus deflersii and Hibiscus micranthus grown in Saudi Arabia by applying validated HPTLC method", Elsevier, 2017
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "Pharmacognostical study and phytochemical investigation of launaea mucronata ", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "7) GC-MS and Antimicrobial Activity of Volatile Oil of Apium Leptophyllum (Benth). ", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "17) Phytochemical study and Bioassay of some constituents from Heliotropium Bacciferum Forssk", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "27) Phytochemical and Biological studies of the shells of Arachis hypogae L. Fruits (Pea Nut) Cutivated in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "18) Macro- and Micromorphology of the Leaf, Stem & Root of Heliotropium bacciferum (Forsk). ", لايوجد, 1900
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