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Microbial Tyrosinase: Biochemical, Molecular Properties and Pharmaceutical Applications
Faculty
Science
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Ashraf Sabry Abdelfattah alsaied
Staff Zu Site
Abstract In Staff Site
Journal:
Biomedical & Pharmacology Journal Published by Oriental Scientific Publishing Company
Volume:
Keywords :
Microbial Tyrosinase: Biochemical, Molecular Properties , Pharmaceutical Applications
Abstract:
Tyrosinase is a copper-containing monooxygenase involved in the catalysis of the hydroxylation and oxidation reaction of monophenols and diphenols, respectively, into O-quinones intermediates. Tyrosinase is mainly involved in melanogenesis via two reactions. Firstly, 3,4- dihydroxyphenylalanine is produced through tyrosine hydroxylation then it oxidized into dopaquinone, and finally gives melanin. However, dopaquinones can results in neuronal damage and cell death through the excessive production, suggesting that tyrosinase may be implanted in the formation human brain’s neuromelanin and association with Parkinson’s diseases. Thus, down regulating the melanin pigments and its intermediates by inhibiting tyrosinase activity is the major pharmaceutical challenge to prevent hyperpigmentation, in addition to therapy of neuromelanin disorders. Thus, this review has been focused on exploring the biochemical and molecular properties of tyrosinase from different sources and its potential inhibition with different natural and synthetic compounds.
Author Related Publications
Ashraf Sabry Abdelfattah alsaied, "Characterization of Homocysteine γ-Lyase from Submerged and Solid Cultures of Aspergillus fumigatus ASH (JX006238)", Korean Society of Microbiology and Biotechnology, 2013
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Ashraf Sabry Abdelfattah alsaied, "Purification and Characterization of LAmino Acid Oxidase from the SolidState Grown Cultures of Aspergillus oryzae ASH1", Pleiades Publishing, LTD, 2013
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Ashraf Sabry Abdelfattah alsaied, "Microbial L-methioninase: production, molecular characterization, and therapeutic applications", Springer-Verlag 2010, 2010
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Ashraf Sabry Abdelfattah alsaied, "Characterization and immobilization of purified Aspergillus flavipes L-methioninase: continuous production of methanethiol", The Society of Applied Microbiology, 2011
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Ashraf Sabry Abdelfattah alsaied, "L-methioninase production by Aspergillus flavipes under solid-state fermentation", Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim, 2009
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Department Related Publications
Mohamed Farouk Ibrahim Aly, "Production of Cellulases and Xylanase by Thermophilic and Alkaliphilic Bacterial Strains Isolated from Agricultural Wastes", World Applied Sciences Journal, 2013
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weSam AbelGhani Aly, "Biosorption of Some Heavy Metal Ions Using Bacterial Species Isolated from Agriculture Waste Water Drains in Egypt", INSInet Publication, 2009
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Fifi Mohamed Reda Mohamed, "Detoxification of enterotoxigenic Bacillus cereus (JX455159) isolated from meat by a local strain of Lactobacillus plantarum (JX282192)", springer, 2013
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Fifi Mohamed Reda Mohamed, "Purification and characterization of a metallo-protease produced by Exiguobacterium sp. S8 (AB813715) isolated from soil", Egypt, 2013
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Ashraf Sabry Abdelfattah alsaied, "L-glutaminase production by Trichoderma koningii under solid state fermentation", Springer, Association of Microbiologists of India 2009,, 2008
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