Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities

Faculty Pharmacy Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Samy Megahed Ibrahiem Elsayed Sakr
Journal: Bioorganic Chemistry ُElsevier Volume:
Keywords : Quinazolinone dimers , , potential , class , safer , inhibitors: Overcoming    
Abstract:
The discovery of more selective and safer voltage-gated potassium channel blockers is an extremely demanding approach. Designing selective Kv1.5 inhibitors is very challenging as only limited data is available on this target due to a lackin
    
     
 
       

Author Related Publications

  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY, 2010 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "SYNTHESIS AND EVALUATION OF 2, 3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS", ajrc, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More

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