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Stabilized-chitosan selenium nanoparticles efficiently reduce renal tissue injury and regulate the expression pattern of aldose reductase in the diabetic-nephropathy rat model
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Life science Elseviere
Volume:
Keywords :
Stabilized-chitosan selenium nanoparticles efficiently reduce renal
Abstract:
One of the global alarming prevalent metabolic diseases is Type 2 diabetes mellitus (T2DM) than other diabetes and sustains a substantial burden on public and healthcare systems. This study attempts to endeavor the beneficial effect of chitosan stabilized nanoparticles Ch-SeNPs on combating diabetic nephropathy (DN) after induction of T2DM in rats (DN.STZ-induced T2D). High-fat diet (HFD) and STZ were used for the induction of T2DM in rats, and then they were treated with either metformin alone (MEF) (500 mg/kg b.wt.) or combined with (Ch-SeNPs) (2 mg Se/kg b.wt.) for eight weeks. The microvascular complications in renal tissue of diabetic rats were pronounced by the prevalence of microalbuminuria and elevated levels of urea, creatinine, and BUN. Pronounced oxidative stress with enhanced inflammatory response. In the urine of diabetic rats, a marked increase in Kim 1, β2-microglobulin, and urinary albumin. Renal morphological alterations were observed in all groups upon induction of T2DM, except for the Ch-SeNPs/MEF group showed noticeable improvements. The expression levels of Aldo-keto reductase AKr1B1, profibrotic protein transforming growth factor-β1 (TGF-β1), nestin, desmin, and vimentin, were up-regulated in the diabetic group. Significant down-regulation of their expression and restored antioxidant capacity was observed in the combined-treated group than single treated ones. Ch-SeNPs helped limit the prevalence of TNF-α, IL-6, and IL-1β while used after T2DM induction by STZ and HFD. Ch-SeNPs/MEF co-therapy could effectively guard the kidneys and reduce the renal tissue injury via inhibiting oxidative stress and restoring glucose hemostasis, which indicates a promising line for treating T2DM nephropathy.
Author Related Publications
Amany Abdalaziz , "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Amany Abdalaziz , "Alleviative effects of dietary Indian lotus leaves on heavy metals-induced hepato-renal toxicity, oxidative stress, and histopathological alterations in Nile tilapia, Oreochromis niloticus (L.)", Elsevier B.V., 2019
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Amany Abdalaziz , "Estimation of organochlorine pesticides and heavy metal residues in two species of mostly consumed fish in Sharkia Governorate, Egypt", Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP, 2016
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Amany Abdalaziz , "Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain", elsevier, 2015
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Amany Abdalaziz , "Identification of Species Adulteration in Raw Milk and Butter Using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism", IDOSI Publications, 2015
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Department Related Publications
Hussein Ibrahim Hussin Elbelbesy , "The impact of staphylococcal mastitis on the level of milk IL-6 lysozyme and nitric oxide. ", لايوجد, 1900
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Hussein Ibrahim Hussin Elbelbesy , "Determination of serum progesterone , estrodiol 17-B , cortisol and prolactin during pregnancy in four breeds of rabbits", لايوجد, 1900
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Hussein Ibrahim Hussin Elbelbesy , "Immunoelectron microscopic studies on spore coat protein of bacillus megaterium.", لايوجد, 1900
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