Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Effect of Paracetamol administration on the Rat kidney structure: A Morphological Study
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Abdelmonem Awad Mostafa Hegazy
Staff Zu Site
Abstract In Staff Site
Journal:
Zagazig University Medical Journal Zagazig University Medical Journal
Volume:
27
Keywords :
Effect , Paracetamol administration , , , kidney structure: , Morphological
Abstract:
Aims: To clarify the nephrotoxic effect of paracetamol in adult male albino rats. Methodology: In this study, fourteen adult male albino rats were divided equally into two groups; Control group and paracetamol-treated group. Kidney specimens were processed for biochemical and histological analysis. Results: Administration of paracetamol revealed a noticeable deterioration of both biochemical and histological changes detected in the paracetamol-treated group. The biological changes were in the form of significant increase in serum urea and creatinine levels. The histological changes markedly affected the tubular system; the proximal and distal convoluted tubules showed marked degeneration, dense nuclear staining, cytoplasmic vacuolization and partial loss of the brush borders. Most tubules were dilated, irregular and filled with hyaline casts. Conclusion: Paracetamol made biochemical and histopathological changes in the rats kidneys. These findings revealed that this nephrotoxicity was associated with an increase in oxidative damage and apoptosis.
Author Related Publications
Abdelmonem Awad Mostafa Hegazy, "Our Experience in the Use of Ivermectin in the Fight against COVID-19", SunText Review of Case Reports & Images, 2022
More
Abdelmonem Awad Mostafa Hegazy, "COVID-19: Virology, Pathogenesis and Potential Therapeutics", Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020
More
Abdelmonem Awad Mostafa Hegazy, "Unusual case of absence of suprascapular notch and foramen", European Journal Anatomy, 2020
More
Abdelmonem Awad Mostafa Hegazy, "Diagnostic Significance of Fine Needle Biopsy and Cell Block in Skin and Subcutaneous Nodules", Biomedical Journal of Scientific & Technical Research (BJSTR), 2021
More
Abdelmonem Awad Mostafa Hegazy, "Possible Protective Role of Capsaicin Against High Fat Diet Effects on Liver and Gall Bladder of Adult Male Mice", Egyptian Society of Histology and Cytology, 2021
More
Department Related Publications
Ashraf Saber Bayoumi Hegab, "التاثير المحسن لفيتامين هـ ضد سمنه على التركيب النسيجى للخصيه والنمط الصبغى في الجرذان البيضاء البالغه ", لايوجد, 1900
More
Gamal Mohamed Zain Elabdein, "دراسه باستخدام الميكروسكوب الالكترونى على النشاط الوظيفى لخلايا شيف في الغدة الجار الدرقيه في الفئران قبل اكتمال الهيكل العظمى ", لايوجد, 1900
More
Gamal Mohamed Zain Elabdein, "تكوين الصمام السمعى الظاهر والغشاء الطبلى في الفئران قبل الولادة", لايوجد, 1900
More
Gamal Mohamed Zain Elabdein, "التركيب الدقيق للخلايا المهديه والافرازية لقمع البويضات في الارانب ", لايوجد, 1900
More
Gamal Mohamed Zain Elabdein, "التركيب الدقيق للخصية والبربخ للانسان", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف