The world is currently facing a great challenge of the current COVID-19 pandemic that has swept the world’s population and affected all aspects of life including health and economic affairs. This forced many countries to take measures, including preventing popular gatherings and aspects of life in clubs, universities and schools, and closing their borders, in addition to taking physical distancing measures and wearing face masks to prevent the spread of infection. In this regard, we tried to investigate the effect of ivermectin as a prophylaxis in close contacts of confirmed cases of COVID-19. This depended on some previous reports about potentiality of the medication against viruses and our noticing of its effect in treating or reducing infections among patients particularly those in the early stages of the disease. Furthermore, it is previously approved by WHO and US FDA as a safe drug having no serious reported side effects. Moreover, it has been used previously on large scales for mass prophylaxis against some parasitic diseases such as filariasis in epidemic areas.