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Production and characterization of taxol as anticancer agent from Aspergillus terreus
Faculty
Science
Year:
2019
Type of Publication:
ZU Hosted
Pages:
13(4), 2055-2063
Authors:
Manal Tawfiq Ibrahim
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Pure and Applied Microbiology Dr. M. N. Khan.
Volume:
Keywords :
Production , characterization , taxol , anticancer agent from
Abstract:
Taxol, a diterpenoid was initially isolated from the bark of Taxus brevifolia, approved by FDA in 1994 as a powerful drug for metastatic ovarian carcinoma, breast and lung cancer. However, due to limitations in the production of this drug based on this plant source, the productive potentiality of fungi of this compound opened a new avenue for its commercial production. In this study, among the twenty fungal isolates screened for taxol production, Aspergillus terreus had the highest potentiality to produce taxol (131.2 μg/ml). The productivity of taxol by A. terreus has been maximized by nutritional optimization using inhibitors and growth regulators. The yield of taxol by A. terreus was maximally obtained (0.663μg/ml) by growing the fungal isolate on potato dextrose broth medium, amended with addition of biotin at 150 μg/ml for 20 days. The chemical structure taxol extracted of A. terreus has been verified by proton and carbon NMR, IR and UV analyses. The activity of A. terreus taxol had been assessed towards multiple cell lines, displaying a strong anticancer activity. In conclusion, the productivity of taxol by A. terreus has been greatly improved upon using biotin as chemical modulator, that open a new avenue for commercializing the taxol yield by fungi.
Author Related Publications
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Manal Tawfiq Ibrahim, "The use of Saccharomyces cerevisiae for removing cadmium(II) from aqueous waste solutions", academic journals, 2012
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Mohamed Farouk Ibrahim Aly, "Characterization of Streptomyces isolates causing colour changes of mural paintings in ancient Egyptian tombs", Microbiological Research, 2013
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Ashraf Sabry Abdelfattah alsaied, "L-Methioninase Production by Filamentous Fungi: I-Screening and Optimization Under Submerged Conditions", Springer Science+Business Media, LLC 2008, 2009
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