Use of ivermectin on a wide scale is very safe as previously stated by WHO in control of some parasitic diseases. It has been tested by numerous clinical trials and researches as a therapeutic and prophylaxis for the current pandemic. It can provide a temporary protection but not prolonged immunization. It might protect people from infection at when exposed to cases of COVID-19. In addition, it eliminates the infections in the early stages of the disease. Even in vaccinated individuals who have had COVID-19 infection, they can use it for treatment. To be effective in COVID-19 prophylaxis, it is suggested to be given to all members of community at the same time. Otherwise, it may be taken hen contact with COVID-19 patients or disease-carriers. It is also a call to WHO and US FDA to re-consider their advice against use of ivermectin in prophylaxis of the current pandemic.