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Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha lipoic acid
Faculty
Veterinary Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Asra Mohamed Abdelazim Abedallah
Staff Zu Site
Abstract In Staff Site
Journal:
Folia Morphologica Folia Morphologica
Volume:
Keywords :
Hypothyroidism: morphological , metabolic changes , , testis , adult
Abstract:
The objective of this study is to evaluate the influence of carbimazole-induced hypothyroidism on testis of adult albino rats and the probable protective effect of α-lipoic acid (ALA). The rats were divided into four groups; Control, α-lipoic acid group, carbimazole, and carbimazole+α-lipoic acid groups. Rats were exposed to ALA (60 mg/kg BW) or carbimazole (1.35 mg/kg BW) or both via gavages for 30 days. Morphometric analysis revealed a significant decrease in tubular diameter, germinal epithelium thickness, and interstitial space as compared to the controls. Also, rats exposed to carbimazole showed a significant decline in testicular weight, sperm motility, and count. Also, deterioration of the testicular architecture. ALA supplementation resulted in a significant improvement in the tubular diameter and germinal epithelium thickness, but no significant improvement regarding interstitial space was observed. Another observation was the significant decline in serum testosterone and FSH in the carbimazole group, indicating reduced
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Asra Mohamed Abdelazim Abedallah, "Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats", Asian Pac J Trop Biomed 2015; 5(10): 832-834., 2015
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Department Related Publications
Hussein Ibrahim Hussin Elbelbesy , "The impact of staphylococcal mastitis on the level of milk IL-6 lysozyme and nitric oxide. ", لايوجد, 1900
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Hussein Ibrahim Hussin Elbelbesy , "Immunoelectron microscopic studies on spore coat protein of bacillus megaterium.", لايوجد, 1900
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