Using Methotrexate as an option for medical treatment of ectopic pregnancies has been suggested since 1982. Studies regarding the dose, number of doses of methotrexate and the predictive factors of degree of success of methotrexate in the medical management of ectopic pregnancy are limited. Aim of the present article were; to assess the predictive factors of success and efficacy of methotrexate therapy and to assess the value and efficacy of using lower dose of methotrexate and the suitable number of doses for medical management of ectopic pregnancy. Patients and methods:we included100patients with ectopic tubal pregnancy that were given Methotrexate dosage1mg/kg which was injected intramuscular. After the first injection we asked the patients to return on the 4th day then on the7th day to test the levels of hCG. In case of reduction of the level of β-hCG less than15% on 4th and7th days, patients were given the second methotrexate dose of 1 mg/kg which was also injected intramuscular.. We followed patients until achieving β-hCG target level (