Over the last few decades, the aquaculture sector occupies a privileged place and is considered one of the most rapid sectors in agricultural systems. This increasing in aquaculture production is necessarily needed to increase the production of nutritional feed and intensive aquaculture systems will be more widespread, thus cultured fish will be suffering from different stressors factors as a result of intensification in farm fish. Recently, nutritional scientists used the medicinal plants and their bioactive principles or extracts for many different purposes in aquaculture farms. They exhibited various advantageous properties such as growth-promoting, antimicrobial, immunostimulant, antioxidants, and hepatoprotective activities. Black cumin (Nigella sativa) and its derivatives have some beneficial therapeutic features for farmed fish. Studies concerning the potential effects of N. sativa on fish production and health have been reported. Literature has depicted that growth performance, feed conversion, meat quality can be positively affected by the inclusion of N. sativa or its active principles (i.e., thymoquinone) in fish diet. Additionally, the dietary supplementation of N. sativa or its derivatives in fish diets, not only enhance of the immune responses, improve the biochemical profile in fish blood, protect against the invading pathogenic bacteria, but also help to ameliorate the oxidative stress responses of fish towards heavy metal toxicants that may be present in the aquatic environment. This chapter presents a simple synopsis of the consequence and health values of the application of N. sativa and its derivatives, and it investigates the potentials of the production and improvement of fish farms through the application of certain natural therapeutic products.