The present study aimed to investigate the beneficial effects of supplementing zinc oxide nanoparticles (ZnO-NPs), thyme oil (THO), or their combination on the reproductive parameters, nutrient digestibility coefficients, and some blood metabolites of male Californian rabbits. Results showed an improvement in the nutrients digestibility, liver and kidney functions, testosterone concentration, and semen characteristics (semen volume, sperm motility, vitality, and morphology). ZnO-NPs were more effective in improving the male fertility, while THO showed a marked improvement in nutrient digestibility. Therefore, the inclusion of ZnO-NPs, or THO, or both is recommended for a rabbit feeding regimen to improve the feeding profitability.