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Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Abdelsalam Behery Shoeib
Staff Zu Site
Abstract In Staff Site
Journal:
Alexandria Journal of Veterinary Sciences Alexandria Journal of Veterinary Sciences
Volume:
Keywords :
Protective Role , Curcumin, Glucosamine , Vitamin , , Oxidative
Abstract:
Levofloxacin is considered a strong weapon against several bacterial infections but its serious side effects limit its use. Curcumin, glucosamine hydrochloride (Gls) and vitamin C (Vit C) have strong effective properties. Hence, the study was carried out to assess their protective roles on levofloxacin adverse effects in immature albino rats. Fifty immature male albino rats were divided into five equal groups: I- Control group (received sterile saline solution) orally; II- Levofloxacin group (10mg/kg b.wt) intraperitoneally; III- Levofloxacin + curcumin (200mg/kg b.wt) orally; IV- Levofloxacin + Gls (500mg/kg b.wt) orally; V- Levofloxacin + Vit C (100mg/kg b.wt) intraperitoneally. Rats were euthanized on zero day and 14 days post treatment. The degree of protection was measured using calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and oxidative biomarkers levels. Furthermore, specimens from tendon, joint, ligament and cartilage were collected and subjected to routine histological technique. Levofloxacin significantly decreased Ca concentration and increased P level and ALP activity. Co-administration of curcumin, Gls and/or Vit C restored these biochemical alterations and improved antioxidant defense system. Levofloxacin produced degeneration of collagen fibers of tendons, necrosis of chondrocytes and destruction to lacunae of articular cartilage of joint, degeneration of collagen bundles of ligaments. Curcumin, Gls and/or Vit C were also markedly ameliorated histopathological effect of levofloxacin. In conclusion, curcumin, Gls and/or Vit C exerted protective actions against levofloxacin adverse effects
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Amany Abdelsalam Behery Shoeib, "2- Effects of zinc sources supplementation on performance of broiler chickens.", journal of american science, 2017
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Amany Abdelsalam Behery Shoeib, "Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution", Veterinary World, 2021
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Adel Abdeltawab Khalil Elbadry, "). The pattern of prolactin, FSH, and TSH levels in the male camel fetus (camelus dromdarius).", لايوجد, 1900
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