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Phytochemical Profile, Antioxidant and Cytotoxic Potential of Parkinsonia aculeata L. Growing in Saudi Arabia
Faculty
Pharmacy
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Sahar Abdelaziz Mohamed Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Saudi Pharmaceutical Journal Published by Elsevier B.V. on behalf of King Saud University.
Volume:
Keywords :
Phytochemical Profile, Antioxidant , Cytotoxic Potential , Parkinsonia aculeata
Abstract:
Parkinsonia aculeata L. growing in Saudi Arabia was investigated for its phytochemical profile, antioxidant, and cytotoxic properties. UPLC-ESI-MS/MS was employed as a powerful technique for the characterization of secondary metabolites from a hydroalcoholic extract, dichloromethane, and ethyl acetate fractions of P. aculeata L. aerial parts. Sixty-nine compounds (flavonoids, anthocyanins, phenolics and fatty acids) were detected and characterized; flavonoids were the abundant components in the analyzed samples. The dichloromethane fraction was rich in phenolics as vanillic acid hexoside, flavonols as 3,7-dimthylquercetin, and flavones as 3'-hydroxymelanettin. However, the ethyl acetate fraction was rich in flavonoid-C-glycosides as luteolin-8-C-β-D-glucoside (orientin) and apigenin-8-C-glucoside (vitexin), flavonoid- O , C -diglycosides such as luteolin 7-O-[6''-dihydrogalloyl]-glucosyl-8-C-pentosyl- (1→2)-glucoside and 2''-O-rhamnosyl isoorientin. These compounds were identified for the first time in dichloromethane and ethyl acetate fractions of Saudi P. aculeata L. Additionally, all the samples were assessed for antioxidant activity using DPPH radical scavenging method and for cytotoxic activity through MTT assay. Accordingly, the most active fraction was the ethyl acetate which showed the highest antioxidant activity (SC positive control, ascorbic acid (SC 50 50 = 57.4 ± 1.2 μg/mL) compared with the = 12.4 ± 0.5 μg/mL) and moderate cytotoxicity against HepG-2 (hepatocellular carcinoma) and MCF-7 (breast carcinoma) cell lines with IC μg/mL, respectively compared with cisplatin (IC 50 50 = 56.9 ± 3.1 and 95.8 ± 3.8 = 3.67 ± 0.22 and 5.71 ± 0.57 μg/mL, respectively for both cell lines). The antioxidant and cytotoxic activities may be attributed to the presence of high percentage of phenolic compounds and hydroxylated flavonoids detected in ethyl acetate fraction using UPLS-ESI-MS/MS.
Author Related Publications
Sahar Abdelaziz Mohamed Abdalaziz, "MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT", European Journal of Pharmaceutical and Medical Research, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Anticancer activity and concurrent analysis of ursolic acid, b-sitosterol and lupeol in three different Hibiscus species (aerial parts) by validated HPTLC method", Elsevier, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Chemical Composition and Biological Activities of the Aqueous Fraction of Parkinsonea aculeata L. Growing in Saudi Arabia", Elsevier, 2018
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Sahar Abdelaziz Mohamed Abdalaziz, "Expression of Biphenyl Synthase Genes and Formation of Phytoalexin Compounds in Three Fire Blight-Infected Pyrus communis Cultivars", PLOS ONE, 2016
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Sahar Abdelaziz Mohamed Abdalaziz, "Concurrent analysis of bioactive triterpenes oleanolic acid and b-amyrin in antioxidant active fractions of Hibiscus calyphyllus, Hibiscus deflersii and Hibiscus micranthus grown in Saudi Arabia by applying validated HPTLC method", Elsevier, 2017
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "The production and Biosynthesis of Medical Agents in Tissue Culture a Study", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "8) Macro-and Micromorphology of the Leaf, Stem & Root of Amaranthus Chlorostachys Willed, Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "Macro- and Micromorphology of the Leaf, Stem & Root of Gomphocarpus Sinaicus Boiss. Family Asclepiadaceae. Growing in Egypt", لايوجد, 1900
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Samyah Salah Mohamed Hafez, "The Pharmacognostical study of Launaea Nudicaulis ( L. ) Hook Family", لايوجد, 1900
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