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Neurological alterations induced by formulated imidacloprid toxicity in Japanese quails
Faculty
Science
Year:
2019
Type of Publication:
ZU Hosted
Pages:
84
Authors:
Reham Zakaria Mustafa Mohammed Hamza
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Thermal Biology ElSevier
Volume:
Keywords :
Neurological alterations induced , formulated imidacloprid toxicity in
Abstract:
Agrochemical risk assessment that takes into account only pesticide active ingredients without the spray adjuvants will miss important toxicity outcomes detrimental to non-target species including birds. In the present study toxicity of imidacloprid (IMI) pesticide was evaluated individually and in a mixture with polyethylene glycol (PEG-600) as adjuvant against Japanese quails. Oral intubation was used to obtain concentration-mortality data. Oral intubation was used to obtain concentration-mortality data. Treatments of quails for 24 h with different doses leading to the calculation of LC50 values. PEG enhances the pesticide efficacy and the LD50 value of IMI was 17.02 mg/Kg1, and in combination with PEG it was 15.98 mg/kg−1. In the second phase of the study, the effects of a single acute dose of IMI (1/4 LD50) individually or in a mixture with PEG has a potent effect on the activity of plasma AChE and brain monoamines transmitters. However, the addition of PEG-adjuvant to the selected insecticide has shown more toxic potential, more highly significant decreases in AChE activity and different changes in cortical monoamines concentration. In the present study the maximum significant inhibition of AChE activity, was recorded post 72 h exposure to IMI individually and 96 h in a mixture with PEG and exhibited −37.56% and −32.65% decreases, respectively. Moreover, the oral intubation of IMI individually or in a mixture with PEG caused a significant elevation in the quail cortical NE and 5-HT. The result also showed while the mixture of IMI + PEG induced the more potent effect in DA alterations, IMI individually was more effective in 5-HT changes. Our findings also indicated that PEG exposure induced remarkable changes in the studied monoamines level and the values were significant throughout the tested periods in DA. Moreover, the studied dose level was vigorously affected quail brain cerebral cortex histological structure. When administered individually or in a mixture with PEG, IMI disclosed neural congestion, neuronal degeneration, pyknosis and perivascular cuffing with glial cells
Author Related Publications
Reham Zakaria Mustafa Mohammed Hamza, "Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats", SAGE, 2020
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Reham Zakaria Mustafa Mohammed Hamza, "Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats", SPRINGER, 2021
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Reham Zakaria Mustafa Mohammed Hamza, "Improving the efficacy of garlic extract in African catfish against copper sulfate-induced immunological and histological effects", ElSevier, 2021
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Reham Zakaria Mustafa Mohammed Hamza, "Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies", Plos, 2021
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Department Related Publications
Reham Zakaria Mustafa Mohammed Hamza, "Anti-ulcer and gastro protective effects of fenugreek, ginger and peppermint oils in experimentally induced gastric ulcer in rats", Journal of Chemical and Pharmaceutical Research ( ISSN : 0975 – 7384 ), 2014
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Mahmoud Abdulaaty AbdelMoneim, "Histological and ultrastructural alterations in the antennal gland of the crayfish procambarus clarkii exposed to mercury.", Egyptian Journal of Aquatic Biology and Fisheries, 2005
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Reham Zakaria Mustafa Mohammed Hamza, "Sodium Fluoride Induced Neurotoxicity and Possible Antioxidant Role of Selenium and Curcumin in Male Mice", Oriental publishing group, 2014
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Reham Zakaria Mustafa Mohammed Hamza, "Immunotoxic Effect of Sodium Fluoride and the Mitigating Effect of Selenium and Curcumin in Male Mice", Oriental publishing group, 2014
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Reham Zakaria Mustafa Mohammed Hamza, "Effectiveness of Radiant SC 12% on superoxide dismutase (SOD) and catalase (CAT) activities in storage pest Rice weevil, Sitophilus oryzae L.", IJFAS, 2014
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