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american journal of pharmtech and research
american journal of pharmtech and research
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Abstract: |
The present study focused on the formulation of metoclopramide HCl (MET HCl) loaded oral
wafers (OWs) as a fast dissolving dosage form without drinking water to produce a prompt
improvement of emesis. OWs were prepared by casting technique using Hydroxypropyl
Methylcellulose (HPMC) as a film forming agent and plasticizers like propylene glycol (PG),
polyethylene glycol (PEG) 400 and polyethylene glycol 600. The prepared formulations were
visually inspected and subjected to evaluation parameters such as thickness, weight variation, drug
content, folding endurance, surface pH, tensile strength, mucoadhesiveness, percentage of moisture
absorption, percentage of moisture loss and in vitro release study. G3 batch was selected for
further investigations e.g. DSC, FTIR and in vivo evaluation. The bioavailability of MET HCl
loaded OWs was assessed by measuring the plasma concentrations of MET HCl in different
studied rabbit's groups' .All wafers were transparent, smooth, uniform and flexible. G3 batch (300
mg HPMC, 20% PEG 400) showed the highest tensile strength, percent elongation,
mucoadhesiveness and faster drug release. The pharmacokinetic data of MET HCl loaded OWs
preparation (G3 batch) showed a significant higher Cmax, AUC0-24 and lower Tmax (p<0.001) than
oral plain MET HCl solution. It could be concluded that MET HCl loaded OWs is a promising
fast-release preparation with enhanced rate and extent of drug absorption hence, higher therapeutic
efficiency against vomiting and nausea in pediatrics, especially postoperatively can be expected.
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