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Neurotoxic Outcomes of Subchronic Manganese Chloride Exposure Via Contaminated Water in Adult Male Rats and the Potential Benefits of Ebselen
Faculty
Veterinary Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Walaa Mohamed Alhadi Hassan
Staff Zu Site
Abstract In Staff Site
Journal:
Zagazig Veterinary Journal Springer Science
Volume:
Keywords :
Neurotoxic Outcomes , Subchronic Manganese Chloride Exposure Via
Abstract:
The neurological effects of manganese (Mn) exposure on adults consuming contaminated water remain unclear.Accordingly, the current experiment was planned to explore the neurotoxic consequences of subchronic Mn exposure via contaminated water and to examine whether ebselen (Ebs) improved these outcomes. Rats exposed to oral MnCl2 (50 mg/kg body weight) for 30 successive days exhibited reduced rearing and ambulation. Furthermore, Mn administration increased brain Mn concentrations and induced superoxide dismutase, catalase, and glutathione depletion. Mn administration also increased lipid peroxidation biomarker levels. Additionally, Mn increased interleukin1-β and prostaglandin E2 levels and altered caspase-3 and Bcl-2 expression. Mn intoxication also induced marked gliosis, numerous vacuolations, and disoriented and pyknotic Purkinje cells as well as marked vascular congestion in brain tissue. Meanwhile, intraperitoneal administration of Ebs (15 mg/kg body weight) to Mn-intoxicated rats improved the behavioral performance and oxidative damage as well as inflammatory, apoptotic, and histopathological changes. The above results indicate that Ebs alleviated Mn neurotoxicity via its antioxidant, anti-inflammatory, and anti-apoptotic activities. Therefore, Ebs could represent a promising agent in the prevention of Mn-induced neurotoxicity.
Author Related Publications
Walaa Mohamed Alhadi Hassan, "دراسة التأثير السمى الجينى لمبيدى الحشائش الراوند أب والاستومب على سمك القرموط النيلى", مجلة الطب البيطرى - جامعة الزقازيق, 2014
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Walaa Mohamed Alhadi Hassan, "Inflammatory and oxidative injury is induced in cardiac and pulmonary tissue following fipronil exposure in Japanese quail: mRNA expression of the genes encoding interleukin 6, nuclear factor kappa B, and tumor necrosis factor-alpha", Elsevier, 2019
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Walaa Mohamed Alhadi Hassan, "Mitochondrial DNA D-Loop Variation among Four Sheep Breeds and Evolutionary Relationships with Other Taxa: Forensic Implication", Nexus Academic Publishers, 2019
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Walaa Mohamed Alhadi Hassan, "Possible role of Arthrospira platensis in reversing oxidative stress-mediated liver damage in rats exposed to lead", elseiver, 2018
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Walaa Mohamed Alhadi Hassan, "Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NFkB and Nrf2/HO-1 pathway", Research in Veterinary Science, 2019
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Department Related Publications
Gehan Gamal Elsayed Mostafa , "دراسات سمية علي الاكريلاميد في ذكور الفئران البيضاء ", لايوجد, 1900
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Kholoud Mohamed Ibrahim Elbohy, "دراسات طبية شرعية لتقدير العمر باستخدام الطول التوليميري في الأغنام الرحمانية", لايوجد, 1900
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