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Inflammatory and oxidative injury is induced in cardiac and pulmonary tissue following fipronil exposure in Japanese quail: mRNA expression of the genes encoding interleukin 6, nuclear factor kappa B, and tumor necrosis factor-alpha
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Walaa Mohamed Alhadi Hassan
Staff Zu Site
Abstract In Staff Site
Journal:
Advances in Animal and Veterinary Sciences Elsevier
Volume:
Keywords :
Inflammatory , oxidative injury , induced , cardiac , pulmonary
Abstract:
The phenylpyrazole insecticide, fipronil, isused for the eradication of insects in agriculture, which also exposes various non-target groups such as birds and animals. Our aim was to assess the cardiac and pulmonary consequences of sub-acute administration of fipronil (1∕5 LD50; 2.26 mg/kg) in the Japanese quail for fifteen days and to determine the tissue recovery over a period of 60 days. Fipronil exposure led to a significant decrease in the body weight of the treated birds. Its exposure also induced cardiac and pulmonary damage of varying degrees. Fipronil increased the lipid peroxide (LPO) and nitric oxide (NO) contents as well as indices of tissue injury in the serum of exposed birds. Furthermore, it decreased the antioxidant indices in both the organs. Most of these changes gradually reversed and the histological changes, particularly of the heart, reversed completely by day-60 of recovery. Furthermore, alterations in the mRNA gene expressions of Nuclear factor kappa B (NF-kB), Interleukin 6 (IL-6), and Tumor necrosis factor-alpha (TNF-α) were monitored by quantitative polymerase chain reaction (RT-PCR). In both the tissues, a significant up-regulation of the transcripts was recorded after fipronil administration, which was reversed during the recovery period in the heart tissue except for TNF-a, while the transcripts in the lung tissue declined non-significantly. This study showed that the exposure of Japanese quail to fipronil has a profound negative impact on heart and lung including oxidative injury and tissue inflammation. Fipronil can induce the activity of NF-kB inflammatory -signaling pathway that play a role in the associated tissue inflammation. Although most of the cardiac changes could be reversed after a recovery period of sixty days, the pulmonary changes did not reverse much
Author Related Publications
Walaa Mohamed Alhadi Hassan, "دراسة التأثير السمى الجينى لمبيدى الحشائش الراوند أب والاستومب على سمك القرموط النيلى", مجلة الطب البيطرى - جامعة الزقازيق, 2014
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Walaa Mohamed Alhadi Hassan, "Mitochondrial DNA D-Loop Variation among Four Sheep Breeds and Evolutionary Relationships with Other Taxa: Forensic Implication", Nexus Academic Publishers, 2019
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Walaa Mohamed Alhadi Hassan, "Possible role of Arthrospira platensis in reversing oxidative stress-mediated liver damage in rats exposed to lead", elseiver, 2018
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Walaa Mohamed Alhadi Hassan, "Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NFkB and Nrf2/HO-1 pathway", Research in Veterinary Science, 2019
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Walaa Mohamed Alhadi Hassan, "SCREENING OF SOME DAIRY PRODUCTS IN EGYPT FOR AFLATOXIN-M1 CONTAMINATION AND SOME HEAVY METAL RESIDUES.", IJAR, 2017
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Department Related Publications
Gehan Gamal Elsayed Mostafa , "دراسات سمية علي الاكريلاميد في ذكور الفئران البيضاء ", لايوجد, 1900
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