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Quercetin Mitigates Vanadium-Pentoxide-Induced Oxidative Stress and Reproductive-Hormone Disruption in Male Rats
Faculty
Veterinary Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Walaa Mohamed Alhadi Hassan
Staff Zu Site
Abstract In Staff Site
Journal:
Biological Trace Element Research Nexus Academic Publishers
Volume:
Keywords :
Quercetin Mitigates Vanadium-Pentoxide-Induced Oxidative Stress , Reproductive-Hormone
Abstract:
Vanadium pentoxide (VP) is a well-defined industrial pollutant, known to adversely affect the reproductive functions of male. This work was done to study the protective activity of the quercetin against VP; we have studied reproductive alterations associated with VP by oxidative stress and deleterious changes on testicular function. Treatment with VP resulted in a reduction of serum total testosterone and luteinizing hormone (LH), with an elevation in the lactate dehydrogenase (LDH) levels. It led to a prominent spermatogenic arrest, decreased the motility percent of sperm and count, and also increased the sperm abnormality. The testicular acid phosphatase was elevated, and reduced glutathione (GSH) and catalase (CAT) levels were reduced, whereas malondialdehyde levels elevated. Additionally, VP reduced actin testicular cytoskeleton immunostaining in myoid cells. In response to concurrent treatment with quercetin and VP, serum hormones, LDH, and sperm quality were improved. Moreover, it reduced oxidative stress by reduction of malondialdehyde and elevation of GSH and CAT activity. Besides, increased actin cytoskeleton immunostaining in myoid cells.
Author Related Publications
Walaa Mohamed Alhadi Hassan, "دراسة التأثير السمى الجينى لمبيدى الحشائش الراوند أب والاستومب على سمك القرموط النيلى", مجلة الطب البيطرى - جامعة الزقازيق, 2014
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Walaa Mohamed Alhadi Hassan, "Inflammatory and oxidative injury is induced in cardiac and pulmonary tissue following fipronil exposure in Japanese quail: mRNA expression of the genes encoding interleukin 6, nuclear factor kappa B, and tumor necrosis factor-alpha", Elsevier, 2019
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Walaa Mohamed Alhadi Hassan, "Mitochondrial DNA D-Loop Variation among Four Sheep Breeds and Evolutionary Relationships with Other Taxa: Forensic Implication", Nexus Academic Publishers, 2019
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Walaa Mohamed Alhadi Hassan, "Possible role of Arthrospira platensis in reversing oxidative stress-mediated liver damage in rats exposed to lead", elseiver, 2018
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Walaa Mohamed Alhadi Hassan, "Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NFkB and Nrf2/HO-1 pathway", Research in Veterinary Science, 2019
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Department Related Publications
Ali Heder Abdelrahman Abohaded, "Detection and Distribution of the Rodenticide Klerat in Rat Tissue", لايوجد, 1900
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Magdy Fekry Aboelfotoh, "ozonides possible intermediates in ozone-induced toxicity in albino wistar rats", لايوجد, 1900
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Magdy Fekry Aboelfotoh, "profenofos exposure suppressed testicular functions in mature male rats", لايوجد, 1900
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Mervat Hassan Hassanien Ghonem , "Effect of cassava leaves (Manihot esculenta) extract in female albino rats", لايوجد, 1900
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