Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Association of serum ferritin with insulin resistance in offsprings of type 2 diabetics
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
136–141
Authors:
Ayman Magdeldin Mohamed Sadek
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Internal Medicine Wolters Kluwer - Medknow
Volume:
31
Keywords :
Association , serum ferritin with insulin resistance
Abstract:
Context Type 2 diabetes is prevalent worldwide, and insulin resistance (IR) is considered the main player in its pathogenesis. Previous studies suggested a link between iron and IR. Aim The aim was to study serum ferritin level in nondiabetic offsprings, with and without impaired glucose tolerance, of diabetic patients and its relation to IR. Settings and design This is a cross-sectional case–control study carried out in the Internal Medicine Department, Zagazig University Hospitals. Patients and methods A total of 25 completely healthy individuals as a control group and 50 offsprings of patients with type 2 diabetes as a case group were included in the study. The case group was further divided into normal and impaired glucose tolerant offspring subgroups after glucose tolerance test. All of them underwent thorough clinical examination; routine laboratory investigation including complete blood count, liver and kidney function tests, fasting and postprandial blood glucose, serum ferritin, and fasting insulin by enzyme-linked immunosorbent assay; calculation of BMI; and homeostasis model assessment-estimated insulin resistance (HOMA-IR). Statistical package for the social sciences for windows (version 16) was used for statistical analysis. Results Significant increase in mean±SD of serum ferritin, fasting insulin, HOMA-IR, and fasting and postprandial blood glucose levels in impaired glucose tolerant offspring subgroup was observed as compared with both control group and normal glucose tolerant offspring subgroup. Significant positive correlation was found between serum ferritin versus each of BMI, fasting insulin, fasting, postprandial blood glucose, and HOMA-IR in impaired glucose tolerant offspring subgroup. Conclusion Elevated serum ferritin levels in nondiabetic offsprings with impaired glucose tolerance may play a role in the pathogenesis of IR state, which may progress to type 2 diabetes.
Author Related Publications
Ayman Magdeldin Mohamed Sadek, "New Screening Non- Invasive Tool for Nonalcoholic Steatohepatitis in High-Risk Individuals", Zagazig University Medical Journal, 2021
More
Ayman Magdeldin Mohamed Sadek, "Evaluation of Thyroid dysfunction in patients with chronic obstructive pulmonary disease in medical intensive care unit of Zagazig University Hospitals", International Journal of Advanced Research, 2016
More
Ayman Magdeldin Mohamed Sadek, "Serum Kidney Injury Molecule-1 in Hepatorenal Syndrome at Medical Intensive Care Unit of Zagazig University Hospitals", (International Journal of Science and Research (IJSR, 2016
More
Ayman Magdeldin Mohamed Sadek, "IMPACT OF HEALTH EDUCATION ON QUALITY OF LIFE IN EGYPTIAN TYPE 2 DIABETIC PATIENTS", IJAR, 2017
More
Ayman Magdeldin Mohamed Sadek, "Prevalence of occult hepatitis C virus infection in patients who achieved sustained virologic response to direct-acting antiviral agents", Le Infezioni in Medicina, 2018
More
Department Related Publications
Ahmed Adel Hassan Muhamad, "دراسة سريرية مرضية لالتهاب الكبد الهلالى المتكاثر عند الاطفال", لايوجد, 1900
More
Ahmed Adel Hassan Muhamad, "ثبات وظائف الكلى المزروعة فى المستقبلون للكلى ويعالجون بعقار السانداميسون متابعة طويلة المدى", لايوجد, 1900
More
Ahmed Adel Hassan Muhamad, "دراسة الاجسام المضادة لمضادات الكارديولابيبين ومتلازمة الكارديولابيبين فى مرضى الروماتويد المفصلى", لايوجد, 1900
More
Ahmed Adel Hassan Muhamad, "الاجسام المضادة السامة للخلايا الليمفاوية للزوج فى حالات ارتفاع ضغط الدم المصاحب للحمل", لايوجد, 1900
More
Ahmed Adel Hassan Muhamad, "تأثير من انظمة التثبيط المناعى على انتاج مادة عوامل النمو المحولtof-B1 فى متلقى زرع الكلى", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف