Journal: |
Zagazig University Medical Journal
Zagazig University Medical Journal
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Volume: |
27
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Abstract: |
Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver
disease which includes simple steatosis and nonalcoholic steatohepatitis
(NASH). The current study aimed to develop a non-invasive tool to predict
NASH in patients with NAFLD. Patients and Methods: A cross-sectional
study was carried on (80) patients presenting to the Hepatology /Internal
Medicine Outpatient Clinic, Zagazig University Hospitals suffering from
dyspeptic symptoms, fatigue and unexplained elevation of aminotransferases
from July 2019 to January 2020. All patients were subjected to liver function
tests, lipid profile, fasting blood sugar, serological markers, abdominal ultrasonographic examination and Fibroscan evaluation. The new model score
included the following clinical and laboratory parameters [body mass index
(BMI), US of liver, Liver stiffness, low-density lipoproteins (LDL), highdensity lipoprotein (HDL), triglyceride (TG), Alanine transferase (ALT),
Aspartame transaminase (AST), AST/ALT ratio, Platelet, mean platelet
volume (MPV), Ferritin and Fasting Blood Glucose] Results: current results
showed a sensitivity of thenew score in the detection of NASH (97.9%) versus
91.7% and 89.6% for NAFLD score and BARD score respectively, but
GULAB score was associated with a 100% sensitivity, at a cutoff level of
1.5. The area under the curve for the new score was is 0.789 versus 0.921,
0.925, and 0.996 for NAFLD, BARD, and GULAB scores respectively.
Conclusion: The new model score considered simple, non-invasive and lowcost tool and can be used as a good negative test to exclude NASH in the
screening of high risk patients and markedly reduce the need for liver
biopsies in NAFLD patients.
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