Journal: |
Le Infezioni in Medicina
Wolters Kluwer - Medknow
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Volume: |
26
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Abstract: |
Context
The pathogenesis of diabetic nephropathy (DN) is still incompletely understood.
Few studies have linked the cellular inflammatory markers, interleukin 6 (IL-6) and
highly sensitive C-reactive protein (hs-CRP), to the development of DN.
Aim
We aimed to explore the link among IL-6, hs-CRP, and grades of DN in both types of
diabetes mellitus (DM).
Settings and design
We carried out a case–control study on participants selected from the outpatient
clinic of Internal Medicine Department.
Patients and methods
We worked on 91 participants, comprising 78 patients and 13 controls. The patient
group was further subdivided into two subgroups: subgroup I [39 patients type 1 DM
(T1DM)] and subgroup II [39 patients type 2 DM (T2DM)]. Each subgroup was
categorized according to the urinary albumin excretion rate into three divisions: A
(<20 μg/min), B (20–200 μg/min), and C (>200 μg/min). We applied history taking,
clinical examination, routine investigation, and IL-6 with hs-CRP testing to all
participants.
Statistical analysis
We used Shapiro–Wilk test, χ2 test, Student’s t test, one-way analysis of variance,
Kruskal–Wallis test, least significant difference test, and Pearson’s correlation
coefficient for data analysis.
Results
Despite the significant difference of laboratory data between patient and control
groups, least significant difference analysis revealed a nonsignificant difference
between patients with T1DM and those with T2DM. On the level of the in-groups
analysis, the most significant key players were hs-CRP and IL-6 among the three
urinary albumin excretion rate categories of patients with T1DM and T2DM, with P
values less than 0.01.
Conclusions
We concluded that IL-6 and hs-CRP might be used as sensitive markers for the
development of DN.
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