Highly efficient methanization of sewage sludge has been a long-standing challenge. Therefore, in this study, hyperthermophilic(70°C)biologicalhydrolysispretreatmentwasinvestigatedasastrategytoimprovesludge biodegradabilitywhensubsequentlycombinedwithananaerobicmembranebioreactor(AnMBR).Itseffectson organicsremoval,methaneyield,microbialcommunitystructureandactivitywerestudiedathydraulicretentiontimes(HRTs)rangingfrom5to20days.Theresultsobtainedfromthe170-daycontinuouslyfedexperiment showedahighmethaneyield,rangingfrom176to246L/kg-VSin,intheAnMBRbyfeedingthepretreatedsludge ataconstantHRTof5days.Highremovalefficienciesofvolatilesolidsrangingfrom46%to63%occurredinthe AnMBR. A satisfactory net energy output was also obtained. Methanothermobacter dominated the AnMBR and was robust to the HRT changes. Severe membrane fouling occurred after 140days under a high solid concentration. Subsequently, chemical cleaning (NaClO and citric acid) successfully recovered the flux and permeabilityofthemembrane.Conclusively,thisstudylaysthefoundationforusinghyperthermophilichydrolysis inthemechanizationofsludgethroughintegrationwithAnMBRtechnology.