1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Samy Megahed Ibrahiem Elsayed Sakr
Journal: bioorganic chemistry elsevier Volume:
Keywords : 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives , anti-inflammatory , analgesic agents    
Abstract:
The design and synthesis of a new series of 1,4-dihydroquinazolin-3(2H)-yl benzamide derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are reported. The target compounds (4a–o) were synthesized using a tw
    
     
 
       

Author Related Publications

  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY, 2010 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "SYNTHESIS AND EVALUATION OF 2, 3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS", ajrc, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More
  • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More

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