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1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study
Faculty
Pharmacy
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Staff Zu Site
Abstract In Staff Site
Journal:
bioorganic chemistry elsevier
Volume:
Keywords :
1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives , anti-inflammatory , analgesic agents
Abstract:
The design and synthesis of a new series of 1,4-dihydroquinazolin-3(2H)-yl benzamide derivatives (4a–o) as anti-inflammatory and analgesic agents and COX-1/2 inhibitors are reported. The target compounds (4a–o) were synthesized using a tw
Author Related Publications
Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016
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Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013
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Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010
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Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013
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Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013
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Department Related Publications
Hanan Hamdy Mahmoud Ibrahiem, "Study on the Molecular Mechanisms Involved Renal tissue injury", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "Effect of lansoprazole on gastric secretion, prostaglandin £2 and plasma", لايوجد, 1900
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Nabila Noureldeen Mostafa Elmaraghy, "Pharmacological Studies on the possible Interactions between Some Analgesics", لايوجد, 1900
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Mohammed Nagieb Mohamed Zakarya Hassan , "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013
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Hany Mohamed Abdelmalek Mahmoud ElBassossy, "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013
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