RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: Oncogene Springer Nature. Volume:
Keywords : RAD6 promotes , repair , stem cell signaling    
Abstract:
Ovarian cancer (OC) is the most deadly gynecological cancer and unlike most other neoplasms, survival rates for OC have not significantly improved in recent decades. We show that RAD6, an ubiquitin-conjugating enzyme, is significantly over
    
     
 
       

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  • Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016 More
  • Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013 More

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