Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Eman Salah Abdelaziz Souliman
Journal: Molecular Cancer Therapeutics American Associatiion of Cancer Research Volume:
Keywords : Synthesis , Evaluation , , Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide    
Abstract:
15-deoxy, Δ12,14-prostaglandin J2-ethanolamide, also known as 15-deoxy, Δ12,14-prostamide J2 (15d-PMJ2) is a novel product of the metabolism of arachidonoyl ethanolamide (AEA) by COX-2. 15d-PMJ2 preferentially induced cell death and apoptos
    
     
 
       

Author Related Publications

  • Eman Salah Abdelaziz Souliman, "Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms", Experimental Pharmacology and drug discovery, 2017 More
  • Eman Salah Abdelaziz Souliman, "Arachidonoyl-ethanolamide activates endoplasmic reticulum stress-apoptosis in tumorigenic keratinocytes: Role of cyclooxygenase-2 and novel J-series prostamides.", wiley online library, 2016 More
  • Eman Salah Abdelaziz Souliman, "Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth.", Elsevier, 2013 More
  • Eman Salah Abdelaziz Souliman, "Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling.", wiley online library, 2016 More
  • Eman Salah Abdelaziz Souliman, "Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice.", Elsevier, 2016 More

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