Forty eight male Wistar strain albino rats 130- 150 g wereobtained from the Animal Breeding House of the National ResearchCentre (NRC), Dokki, Cairo, Egypt. They were maintained on basalration and tap water ad-libitum and photoperiod 12L/12D cycle. Thepresent study was carried out to evaluate the protective antioxidanteffect of AGE to ameliorate the deleterious effects and restoring thealtered biochemical enzyme activities in CPF induced toxicity in malealbino rats with regard to its effects on the body weight, male fertility,oxidative stress, DNA damage (comet assay and detection of 8hydroxy- 2deoxyguanosine) and histopathological studies of lungs,brain, kidneys and testes.1. Effects on body weightsThere were non significant differences in body weightsbetween the eight groups at the beginning of the experiment. Thepresent study revealed that after oral administration of CPF to malerats significantly decreased the mean body weight compared with thecontrol group except at the low dose the decrease was non significantat 2 and 4 weeks only. Decreased body was time and dose dependentas. AGE administered rats showed non significant increase in bodyweights than control rats. Administration of AGE plus CPFnormalized body weights to within the normal limits2. Effect on male-fertllity>Regarding the sperm motility percentage of male albino ratsorally administered CPF had a significant decrease in sperm motilitypercentage with high and medium doses of CPF administration whilelow dose of CPF: showed. non significant decrease in motility