A total of 60 Adult male Sprague-Daley rat weighting 200-250gm were used in this Experiment. This animals were obtained from the Centeral Animals House of Faculty of Veterinary MedicineZigzag University. Animals were maintained in stainless steel cages inthe biochemistry Department under. hygienic condition. The animalsreceived standard rats pellet diet and water labiturh. Rats under studywere randomly divided in to six groups according to treatment. The rats were acclimatized for 2 days and randomly divided to six groups of ten animals each set up as follow: The animals were divided into SIX groups of ten rats each.Group I was injected with saline intraperitoneally. This group servedas control. Groups 11 was treated with GSH for 15 days and then received CP plus GSH for 5 days., Groups III was treated with CV for 15 days then injected with CP plus VC for 5 days. Groups IV was treated with CP plus GSH for 5 days. This group treated wiGroup VI was treated with CP only for 5 days. Blood samples werecollected in heparinized tubes from the rats killed 7 days after Cl’ orsaline administration and their kidneys were removed and kept in anice bath until homogenization. Serum was used for the estimation ofurea and creatinine and kidney tissue for the determination of contentsof renal MDA, GSH-Px, GSH, CAT and SOD.