SYNTHESIS OF NOVEL PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES AND THEIR IN VITRO ANTIMICROBIAL AND CYTOTOXIC EVALUATION

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Amany Mohamed Mohamed Elmahmoudy Sanger
Journal: World Journal of Pharmaceutical Research www.wjpr.net Volume:
Keywords : SYNTHESIS , NOVEL PYRIMIDINE , FUSED PYRIMIDINE DERIVATIVES , THEIR    
Abstract:
In the present work some novel pyrimidine and fused pyrimidine derivatives were prepared starting from 1-allyl-2-hydrazinyl-4-oxo-6- (3, 4, 5-trimethoxyphenyl)-1, 4-dihydropyrimidine-5-carbonitrile (4) the key intermediate. The structure
    
     
 
       

Author Related Publications

  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors", mdpi, 2022 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates", mdpi, 2022 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives as Potential Apoptotic Antiproliferative Agents", Bentham Science Publishers, 2022 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRAZOLINE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AND ANTITUMOR AGENTS", www.wjpr.net, 2016 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Synthesis, cytotoxic and antimicrobial activity of some new 3,4,5-trimethoxybenzyl-1,2,4- triazines and their condensed derivatives", www.cbijournal.com, 2011 More

Department Related Publications

  • Tarek Mohamed Salah Rashad, "Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1H-Benzotriazole-1-carboximidamides", Wiley-VCH GmbH, 2020 More
  • Tarek Mohamed Salah Rashad, "Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors", ELSEVIER, 2019 More
  • Tarek Mohamed Salah Rashad, "Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone-dichloroacetic acid hybrids.", Wiely, 2019 More
  • Tarek Mohamed Salah Rashad, "Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold", 2020 Elsevier, 2020 More
  • Yasmina Elsayed Mohamed Mansour Lashien, "synthesis molecular docking and anti inflammatory screening of novel quinoline incorporated pyrazole derivatives using Pfitzinger reaction II", Bioorganic Chemistry, 2014 More
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