Cefotaxime has proved to be one of the most valuable drugs for the treatment of severe respiratory infection, urogenital infection, meningitis and septicemia and also piroxicam has beenproved to be one of the most valiable drug for analgesic, anti- inflammatory and antipyretic action. The combination between the two drugs could be used for treatment of infection and reliefof pain.The present study was contrived to study the adverse effects of cefotaxime, piroxicam and both of them on developing pregnant rats and their foeti .In the present study forty mature female rats were mated with twenty male rats.On the first day of gestation which detected by vaginal smears; the females were divided into 4 equal groups each of ten as the following:-1st group: was injected intramuscularly from the 6th to 15th day of gestation with cefotaxime (3.8mg/200gm b.wt/12hrs /day).td group: was injected intramusculalry from 6th through 15th day of gestation with piroxicam (0.18mg/200gm b.wt/12hrs/day). !’3rd group: was injected intramuscularly from 6th through 15th day of gestation with both cefotaxime ((3.6mg/200gm b.wt! 12hrs /day) and piroxicam (0. 18mg/200gm b.wt! 12hrs /day).4th group: Received no medication and considered as control.