Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Amr Selim Ahmed Ali Abu Lila
Journal: Cancer Letters Elsevier Volume:
Keywords : Metronomic , dosing , thymidylate synthase silencing have synergistic    
Abstract:
Metronomic chemotherapy is currently considered an emerging therapeutic option in clinical oncology. S-1, an oral formulation of Tegafur (TF), a prodrug of 5-fluorouracil (5-FU), is designed to improve the antitumor activity of 5-FU in ta
    
     
 
       

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