The present study was carried out on 45 clinically healthydogs of different age, sex and body weight.All animals were operated u~on for cholecystectomy throughabdominal approach the animals were divided into 3 groups, eachof 15 dogs, ar c or-d.l ng to the site of laparotomy the incision wasde ne namely; midline, parailledian and cresoentic ,araoostal.In addition to the surgical-techmique, the present work wasaimed to study some serum biochemical variations and pathoanatomical and histopahological findings were also recerded beforeand after operations.All operated dogs withstood well the surgical interventionand manifested no post operative conilcations during the CDurseof the experiments that lasted for 30 - 60 days •The abdominal ih digs of all groups healed by primaryintenti~n eXc8pt tow cases in which the healing process was retardedfrom the results of the present experiments, it becameevident that the crescentic paracostal laparotomy inc-ision wasthe most reliable approach to cholecystectomy operation in thedog through such approach it was easy to visullize, reach andmanipulate the gall bladder facilitatin~ its removal!Blunt dissection of the rectus adb abdominis and thetransverse abdomisis muscle parallel with their fibers, ~nsteadof their cutting, has illc.intaineci its antomic8.l fctioh. Inaddition, this procedure prevented severinc of crc:mia1 epigast-ric vessels. The caudal retraction of the iC~8stions ttiat wasproduced by raising the front part of the body, gIsatly faci1i-