Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins.

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages: 484-496
Authors:
Journal: Scientia Pharmaceutica scipharm.at Volume: 2016
Keywords : Benzotriazole-Mediated Synthesis , Antibacterial Activity , Novel N-Acylcephalexins.    
Abstract:
Cephalexin (1) was acylated using N-acylbenzotriazoles (3a–k′) derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%–96%). Antibacterial screening o
   
     
 
       

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  • Tarek Mohamed Salah Rashad, "Chemical ligation of S-acylated cysteine peptides to form native peptides via 5-, 11-, and 14-membered cyclic transition states.", American Chemical Society, 2011 More
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