Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration

Faculty Pharmacy Year: 2013
Type of Publication: ZU Hosted Pages: 235-42
Authors:
Amr Selim Ahmed Ali Abu Lila
Journal: International Journal of Pharmaceutics Elsevier Volume: 1
Keywords : , , polyglycerol (PG), instead , polyethylene glycol (PEG),    
Abstract:
The accelerated blood clearance (ABC) phenomenon accounts for the rapid systemic clearance of PEGylated nanocarriers upon repeated administrations. IgM production against the polyethylene glycol (PEG) coating in PEGylated liposomes is now k
    
     
 
       

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