SYNTHESIS AND REACTIONS OF 2-AMINO-4-ARYL-5,6,7,8-TETRABROMO-1(2H)-PHTHALAZINONE DERIVATIVES

2-Amino-4-aryl-5,6,7,8-tetrabromo-1(2H)-phthalazinones (3a-c) have been prepared via the interaction of benzoxazones (2a-c) with, hydrazine hydrate in boiling pyridine. The reaction of 3a with carbon disulphide and hydrazine hydrate in the presence of liquid ammonia gives 2-thiosemicarbazide phthalazinone derivative 4. Also, the reaction of 3a separately with phenyl isothiocyanate, chloroacetyl chloride and alpha-chloroacetanilide gives the corresponding N-phenylaminocarbothiamido-, alpha-chloroacetamido, and N-phenylcarbamoylmcthylaminophthalazinones (6, 9, 11). The biological activity of some compounds has been described.