SYNTHESIS AND REACTIONS OF 3-AMINO-2-METHYL-4(3H)-QUINAZOLINONE DERIVATIVES

3-Amino-2-methyl-4(3H)-quinazolinone (2) has been synthesized by treating 2-methylbenzoxazinone (1) with hydrazine hydrate. Reaction of quinazolinone (2) with phenyl isothiocyanate and phenyl isocyanate furnish the corresponding aminocarbothiamide and aminocarbamide derivatives (3 and 5), respectively, which on reaction with malonic acid in acetyl chloride afford thiobarbituric and barbituric acid derivatives (4 and 6), respectively. Behaviour of compound 5 towards different aldehydes, ketones and imides have been investigated.