Reaction of acyl isothiocyanates with nucleophiles: A convenient synthesis of 1,3-oxazine, pyrimidinethione and thiazole derivatives

Faculty	Science	Year:	1996
Type of Publication:	Article	Pages:	15-20
Authors:	ASSY, MG	DOI:	10.1080/10426509608029633
Journal:	PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS GORDON BREACH SCI PUBL LTD	Volume:	108
Research Area:	Chemistry	ISSN	ISI:A1996VH77600003
Keywords :	acyl isothiocyanate, 1, 3-oxazine, thiazole
Abstract:	The reaction of acetyl isothiocyanate 1 with ethyl cyanoacetate, malononitrile and/or a cyclic beta-diketone afforded the corresponding 1,3-oxazines 3, 11 and thioamide 12 respectively. The heteroannulation of 3 and the synthesis of thiazole 18 is described.
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