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Study of Non-organ-specific Antibodies in Children with Genotype 4 Chronic Hepatitis C
Faculty
Medicine
Year:
2013
Type of Publication:
Article
Pages:
262-270
Authors:
Hamed, Mohammed E, Alanani, Naglaa M. Kama, Sherief, Laila M, Fouad, Mohammed A, Elwahab, Lamiaa A, Raafat, Nermin
DOI:
10.4103/1319-3767.121038
Journal:
SAUDI JOURNAL OF GASTROENTEROLOGY MEDKNOW PUBLICATIONS \& MEDIA PVT LTD
Volume:
19
Research Area:
Gastroenterology \& Hepatology
ISSN
ISI:000327579900005
Keywords :
Children, Egypt, genotype 4, hepatitis C, non-organ-specific antibodies
Abstract:
Background/Aim: Adult studies established a relationship between hepatitis C virus (HCV) infection and the presence of non-organ-specific antibodies (NOSAs). Most studies were carried out on genotypes 1 and 2. Only a few studies addressed that issue in pediatrics. No studies have been carried out on autoimrnunity and genotype 4 in children. We aim to investigate NOSAs in 80 Egyptian children with chronic HCV infection along with studying the underlying genotype of HCV, and correlating autoimmunity with the epidemiological, clinical, biochemical, and virological features. Materials and Methods: HCV-RNA was assayed by the polymerase chain reaction and viral genotypes were determined. NOSAs were measured and liver biopsies were taken for histopathological examination. Results: Genotype 4 was the only detected genotype in the included 80 patients. Anti-smooth muscle antibodies (ASMA) were the only detected antibodies in 32 (40\%) patients, always with V specificity (vessels only) at titers ranging from 1:20 and 1:160. Anti-nuclear antibodies (ANA) and liver-kidney microsomal antibodies-1 (LKMA-1) were not detected in any of our patients. Epidemiologic and clinical features did not significantly differ between autoantibody-positive and -negative patients. Among biochemical features, significantly high levels of total bilirubin, albumin, immunoglobulins, alkaline phosphatase, and gamma-glutamyl transpeptidase were found in the antibody-positive group. Conclusion: Genotype 4 HCV is the prevailing genotype in Egyptian children with chronic HCV infection. A consistent proportion of these children with chronic HCV infection circulate non-organ-specific autoantibodies. The prevalence of ASMA and the absence of ANA and LKMA-1 might be related to the unique situation in Egypt with unique prevalence of genotype 4. More studies are warranted on larger pediatric population to validate these findings.
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