Background: several methods of weight reduction appeared in the past few decades either surgical or non-surgical techniques, many of them resulting in unplanned rapid weight reduction with loss of fat cushion around common peroneal nerve (CPN) resulting in foot drop (Slimmer’s palsy). The current study evaluated the clinical outcome after CPN decompression for Slimmer’s palsy. Methods: This study was conducted on seven patients (9 legs), (2 males & 5 females) with foot drop after rapid weight reduction attended to the Orthopedics and Traumatology department from 2021 to 2023. Seven patients with foot drop following rapid weight loss were confirmed by a nerve conduction study, and there were no local causes on the knee X-ray. Results: Following surgical decompression ankle, toes dorsiflexion and foot eversion were improved together with improvement of nerve conduction in electrophysiological data. Conclusion: Although it is rare, loss of the fat cushion around the nerve results in conduction deficit. Surgical decompression improves nerve conduction and correct foot drop.