Association of PON1 gene polymorphisms, paraoxonase 1 gene expression and activity in Egyptian children and adolescents with sickle cell disease

Faculty	Medicine	Year:	2026
Type of Publication:	ZU Hosted	Pages:
Authors:	Staff Zu Site Abstract In Staff Site
Journal:	BMC pediatrics BMC pediatrics	Volume:

Keywords :	Association , PON1 gene polymorphisms, paraoxonase , gene
Abstract:	Sickle cell disease (SCD) is defined by chronic oxidative stress, hemolysis, vaso-occlusive crisis (VOC), endothelial injury, and end-organ damage. Paraoxonase1 (PON-1) serves a significant function as an anti-inflammatory and antioxidant agent. This study investigates PON1c.55L > M and PON1c.192Q > R polymorphism frequency in Egyptian children and adolescents with SCD, as well as the impact of these polymorphisms on PON-1 gene expression and enzymatic activity.

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