The current study aimed to examine the impact of high performance work systems’ practices (skill enhancement practices - motivation enhancement practices and participation enhancement practices) on the job satisfaction of faculty members in private universities, as well as to examine the impact of job stress on this relationship between high performance work systems’ practices and job satisfaction. The research community represented in four Egyptian private universities and the research sample amounted to 338 faculty members in Egyptian private universities. there was 265 valid questionnaires with a response rate of 78% .The responses were analyzed statistically, and results indicated that there is a positive relationship between high performance systems’ practices and job satisfaction, while there is a negative relationship between job satisfaction and job stress, also results confirmed the moderating role of job stress in the relationship between high performance systems’ practices and job satisfaction.