In the light of the main study results; it can be concluded that the highest percentage of nurses expressed a moderate level of perception toward artificial intelligence while, digital health literacy was at desirable level. In addition, nurses’ innovative behavior was found to be at a moderate level. Furthermore, the study revealed a statistically significant and direct correlation between artificial intelligence with digital health literacy and nurses’ innovative behavior, as well as a statistically significant and positive correlation between digital health literacy and nurses’ innovative behavior. These findings indicate that both artificial intelligence and digital health literacy are important factors associated with nurses’ innovative behavior in the workplace, highlighting the importance of integrating digital competencies and advanced technologies to foster innovation in nursing care.