Background: Healthy lifestyle promotion among females, enables attainment of healthy generations. Objectives: To evaluate effect of an educational program about health promoting lifestyle on health outcomes menopausal symptoms among Egyptian females. Method: A quasi-experimental study, was conducted in two directorates in Zagazig district, Sharkia Governorate, Egypt from March to December 2021. A representative sample was drawn by a two-stage sample design. The study was conducted through three phases: pre and post intervention phases for both groups. Within intervention phase, educational program on adopting health promoting lifestyle was applied for the experimental group. Results: There is statistically non-significant difference between both groups regarding mean score of baseline health responsibility, physical activity, nutrition, spiritual growth, interpersonal relation, stress management, total health promotive lifestyles, somatic, psychological, urogenital, and total menopausal rating scale scores. There is statistically significant difference between them regarding means of all domains of both tools after intervention. Within experimental group, there is statistically significant improvement in domains and total scores after intervention. Mean systolic and diastolic blood pressure (SBP, DBP) become significantly lower among experimental group. There is significant decrease in mean BMI, blood sugar, SBP and DBP within experimental group. On the other hand, within control group, there is non-significant change in BMI, SBP, or DBP. Conclusion: Implementing educational interventions based on health-promoting behaviors is an effective technique for reducing illness occurrence and improving women’s postmenopausal health.