The main objective of the research was to measure the effect of uncertainty in economic policy on the relationship between business strategy and financial performance in the Egyptian business environment. The researcher relied on the content analysis method as part of the study's applied methodology, using a sample of (77) listed companies from various sectors on the stock exchange, which includes actual data over a time series extending to (10) years during the study period from (2014 to 2023) with a total of (770) observations. The applied study employed statistical methods to test the research hypotheses by using direct and interactive relationship models through the Ordinary Least Squares (OLS) method and the Generalized Least Squares (GLS) method to test two main hypotheses, based on the construction of four statistical models to measure the relationship between the research variables. The research concluded that economic policy uncertainty not only affects a firm’s financial performance and sustainable growth but also threatens its existence and continuity in the business environment. Therefore, an appropriate business strategy can play a crucial role in mitigating the negative effects of economic policy uncertainty and achieving sustainable financial growth for firms. The results also indicated that a defensive business strategy can mitigate the negative effect of economic policy uncertainty on the financial performance and sustainable growth of Egyptian firms. The results reflect the importance of adopting and implementing the appropriate business strategy, especially during times of economic uncertainty. Based on the previous results, the researcher recommends several key suggestions, the most important of which are: the need for investors, financial analysts, and other stakeholders to look at the business strategies adopted by companies as indicators that can be relied upon to predict the company's financial performance, in addition to the need for economic policy makers to study the effect of changing economic policies on the stability and growth of companies before making a decision to change policies, as these decisions may have negative effects on the performance and financial stability of some companies.