Abstract: The present research aims at conducting an experimental study to demonstrate the effect of using microencapsulation technology (microcapsules) enhanced with vitamin (E) and tetracycline on the functional properties of cellulosic fabrics. Vitamin (E) has received considerable attention recently due to its importance in strengthening the immune system, as it is one of the most important antioxidants that protect body cells from damage and maintain the health of red blood cells. This led us to search for the best methods to acquire the sufficient amount needed by the human body, as well as using tetracycline, which is used in treating skin infections resulting from bacterial infections that cause ulcerations. This was achieved through attempting to treat the fabrics produced under research, which were woven at Misr Spinning and Weaving Company in El-Mahalla El-Kubra with multiple variations. The warp yarn specifications were constant for all fabrics, with the warp yarn count fixed at 1/20 combed cotton English count. The weft yarn count used was 1/30 English count, with 28 picks/cm. The production was carried out with the following variables: • Weft yarn material type (100% viscose - 100% cotton - 50:50% cotton/viscose blend). • Weave structures: plain weave (1/1) - weft rib (2/2) - twill (2/1). The fabric samples produced under research were treated with microencapsulation technology (microcapsules) enhanced with 500 mg of tetracycline and 15% vitamin (E), using different treatment concentrations of microcapsules (0.25 mg/L - 0.50 mg/L - 0.75 mg/L). Several polymers were used to form the microcapsules, such as sodium alginate and gelatin, which form a shell for the microcapsules. Subsequently, a new technique was applied, and the fabrics were treated to improve the functional properties of the product and impart unusual properties and functions. After implementing the fabric samples under research according to the specified specifications and variables, some laboratory tests were conducted to determine the level of functional performance quality for the fabrics produced under research. The data was then statistically processed to study the effect of study factor variables on the functional suitability of the product. The study reached the following results: • The best specifications for the fabrics produced under study that align with the functional properties of the product subject of the study are in a fabric produced with the weave structure blend cotton/viscose (50:50%) and weft yarn material weft rib(2/2) with 75 mg/L with the best composition of the treatment material. Finally, the study presented a set of results and recommendations that, through concerted research efforts, can develop the level of functional performance quality for the fabrics produced under study, thus contributing to the development of textile product quality. The research also recommends the importance of using vitamin (E) in the human body and working on employing it in other scientific research, as well as focusing on treating fabrics and enhancing them with tetracycline. Keywords: Microencapsulation technology - Vitamin (E) – Functional Properties - Tetracycline