The effects of biopesticide Agrine on mitosis, meiosis, yield and seed protein electrophoresis of Vicia faba and Zea mays plants were studied. A decrease in the mitotic index in the root tip meristems of Vicia faba and Zea mays was observed after seed soaked with half recommended (1/2RD), recommended (1RD) and double recommended (2RD) doses of Agrine for 12, 24 and 48 hours. Agrine also induce a range of chromosomal irregularities, their frequencies were dose dependent. The dominant abnormalities induced in dividing cells were chromosomal stickiness and disturbed phases. Agrine has the ability to exert an action on the different stages of meiotic divisions I and II. The chromosomal abnormalities of meiotic division were nearly similar to the corresponding in mitotic division but their frequency was higher. The M1 progeny showed a marked percentage of abnormal cells and reduction in the productivity. These abnormalities were similar to those of parent plants. These results indicate the toxicity of Agrine and its mutagenic potential. The mutagenic effects of Agrine on banding patterns of protein showed many changes such as changes in band intensity, changes in band mobility, appearance of new bands and disappearance of some others.