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Epicardial Adipose Tissue as a New Biomarker for Insulin Resistance and Predictive of Prediabetes النسيج الدهني فوق التامور كعلامة حيوية جديدة لمقاومة الأنسولين و مؤشر تنبؤي لمرحلة ما قبل السكري
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Azza Hassan AbdelFattah
Staff Zu Site
Abstract In Staff Site
Journal:
Zagazig University Medical Journal Zagazig University Medical Journal
Volume:
Keywords :
Epicardial Adipose Tissue , , , Biomarker , Insulin Resistance
Abstract:
Background: Type 2 diabetes is predisposed by increased visceral obesity, insulin resistance, and B-cell dysfunction. Obesity, diabetes mellitus, and the metabolic syndrome are all risk factors for increased epicardial adipose tissue (EAT) thickness. Few published studies have examined the significance of EAT thickness in prediabetic patients and how it relates to insulin resistance, HbA1c levels, and the length of diabetes. Aim: The goal was to look at the relationship between EAT and the likelihood of developing Type 2 DM. Subjects and methods: This study included 69 subjects. Subjects were split into the following three groups: Group I consists of 23 individuals who have good blood sugar levels, Group II consists of 23 patients with prediabetes, and Group III consists of 23 patients with type 2 diabetes. All patients underwent transthoracic echocardiography to estimate epicardial adipose tissue thickness. Results: Our study reveals a statistically significant difference between the tested groups in terms of their thicker epicardial adipose tissue in diabetes than prediabetes group(p<0.05). The median epicardial fat thickness (EFT) was considerably greater in the group of people with prediabetes than healthy control group (p<0.05). There is significant and direct relation between EAT thickness of studied groups as well as HOMA-IR, BMI, and waist size (p<0.05). Conclusion: The EAT is simple, inexpensive, readily available, non-invasive, and a predictor of development of prediabetes and Type 2DM.
Author Related Publications
Azza Hassan AbdelFattah, "Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism", Bentham Science Publishers B.V., 2020
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Azza Hassan AbdelFattah, "The influence of single-nucleotide polymorphisms of interleukin- 1β −511 and +3954 on the susceptibility to Hashimoto’s thyroiditis in Egyptian women: immune-endocrine interactions", Egypt J Intern Med, 2019
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Azza Hassan AbdelFattah, "Association between subclinical hypothyroidism and diabetic nephropathy in type 2 diabetes", The Egyptian Journal of Internal Medicine, 2019
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Azza Hassan AbdelFattah, "Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti-TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism", Endocr Metab Immune Disord Drug Target, 2020
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Amro Shaban Hanafy Elsayed, "Efficacy of a non-invasive model in predicting the cardiovascular morbidity and histological severity in non-alcoholic fatty liver disease", elsevier, 2019
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